Cannabinoid Receptor Type 2 (CB2)
CB2 receptors occur most commonly in the spleen, tonsils, thymus, and immune cells such as mast cells, monocytes, macrophages, B and T cells, and microglia; only a small number exist in the brain.
Changes in CB2 receptor function is synonymous with virtually every type of human disease; be it cardiovascular, gastrointestinal, neurodegenerative, psychiatric, and autoimmune. It even plays a role in liver and kidney function, bone and skin health, cancer, and even pain-related illnesses.
CBD’s Indirect Effects on the Endocannabinoid System
While THC has a strong binding affinity for both CB1 and CB2 receptors, cannabidiol (CBD) has no particular binding affinity. Instead, many of the therapeutic benefits of CBD are created through indirect actions.
These actions include activating TRPV1 Receptors. These receptors are involved in regulating pain, body temperature, and inflammation.
CBD also works to inhibit Fatty Acid Amide Hydrolase (FAAH). This inhibition creates higher levels of endocannabinoids like anandamide. Anandamide, or the bliss molecule, plays a role in the neural generation of pleasure and motivation so it’s appropriate that its name is derived from “ananda,” a Sanskrit word meaning bliss. It also performs other important functions like regulating feeding behaviors and assisting with embryo implantation during the early stages of pregnancy.